The aim of this review was to explore the status of urine sampling as a liquid biopsy for
noninvasive cancer research by reviewing used preanalytical parameters and protocols. We …

The increase in recent scientific studies on cancer biomarkers has brought great new
insights into the field. Moreover, novel technological breakthroughs such as long read …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …

Tumor DNA contains specific somatic alterations that are crucial for the diagnosis and
treatment of cancer. Due to the spatial and temporal intra-tumor heterogeneity, multi …

Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets
the immune checkpoints to re-activate silenced T cell cytotoxicity. In recent pivotal trials …

Changes in DNA methylation have been causally linked with cancer and provide promising
biomarkers for detection in biological fluids such as blood, urine, and saliva. The field has …

Although the routine use of serum prostate-specific antigen (PSA) testing has undoubtedly
increased prostate cancer (PCa) detection, one of its main drawbacks is its lack of specificity …

The coding region of GSTP1 gene is preceded by a large CpG-rich region that is frequently
affected by methylation. In many cancer types, GSTP1 is affected by hypermethylation and …

In order to successfully cure patients with prostate cancer (PCa), it is important to detect the
disease at an early stage. The existing clinical biomarkers for PCa are not ideal, since they …

Significant technological advances in analytical methods and a greater understanding of
molecular carcinogenesis has paved the way toward a new era of disease detection. 1–3 …