[HTML][HTML] Norrin protects retinal ganglion cells from excitotoxic damage via the induction of leukemia inhibitory factor

S Kassumeh, S Leopold, R Fuchshofer, CN Thomas… - Cells, 2020 - mdpi.com
Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in
mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following …

Uncovering the promiscuous activity of IL‐6 proteins: A multi‐dimensional analysis of phylogeny, classification and residue conservation

A Costa, R Franco‐Duarte, R Machado… - Protein …, 2022 - Wiley Online Library
The IL‐6 family of cytokines, known for their pleiotropic behavior, share binding to the gp130
receptor for signal transduction with the necessity to bind other receptors. Leukemia …

[HTML][HTML] Endothelial yes-associated protein 1 promotes astrocyte proliferation and maturation via cytoplasmic leukemia inhibitory factor secretion in oxygen-induced …

JY Zhu, X Chen, X Li, LL Luo, QM Hu… - … & Visual Science, 2020 - tvst.arvojournals.org
Purpose: Purpose The role of endothelial Yes-associated protein 1 (YAP) in the
pathogenesis of retinal angiogenesis and the astrocyte network in the mouse oxygen …

Growth factors and molecular-driven plasticity in neurological systems

DW Zochodne - Handbook of Clinical Neurology, 2023 - Elsevier
It has been almost 70 years since the discovery of nerve growth factor (NGF), a period of a
dramatic evolution in our understanding of dynamic growth, regeneration, and rewiring of …

Shared and oppositely regulated transcriptomic signatures in huntington's disease and brain ischemia confirm known and unveil novel potential neuroprotective …

F Yildirim, M Foddis, S Blumenau, S Müller… - Neurobiology of …, 2021 - Elsevier
Huntington's disease and subcortical vascular dementia display similar dementing features,
shaped by different degrees of striatal atrophy, deep white matter degeneration and tau …

[HTML][HTML] Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes

G Gyetvai, C Roe, L Heikal, P Ghezzi, M Mengozzi - Molecular Medicine, 2018 - Springer
Background The pro-myelinating effects of leukemia inhibitory factor (LIF) and other
cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor …

[PDF][PDF] Investigating the Gliogenic Genes and Signaling Pathways in the Pathogenesis of Huntington's Disease: A Systematic Review

O Shafi, U Yaqoob, M Haseeb, M Madhwani, LN Virk… - 2024 - scholar.archive.org
Background: The pathophysiology of Huntington's disease (HD), a neurodegenerative
condition, is considered to also involve glial cells. Understanding the intricate interactions …

Astrocyte-mediated immune modulation during mycobacterial infection

S Geyer - 2023 - open.uct.ac.za
Central nervous system tuberculosis (CNS-TB) is the severest clinical extra-pulmonary
manifestation of tuberculosis (TB) disease and constitutes approximately 1% of global …

[PDF][PDF] Role of microRNA-27a-5p and-3p in human adipocyte biology

H Wu - 2022 - oparu.uni-ulm.de
This study investigated the role of miRNAs in WAT tissue of mice either fed with normal diet
(ND) or high fat diet (HFD). The expression of the miR-27a genes (miR-27a-5p and-3p) was …

The cytoprotective effects of leukemia inhibitory factor during bacterial pneumonia

E Na - 2022 - search.proquest.com
Pneumonia is a worldwide public health concern representing a leading burden of disease.
During bacterial pneumonia, the alveolar-capillary barrier is critical for maintaining gas …