[HTML][HTML] RNA N6-methyladenosine modification in cancers: current status and perspectives
Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
[HTML][HTML] Wild-type and mutated IDH1/2 enzymes and therapy responses
RJ Molenaar, JP Maciejewski, JW Wilmink… - Oncogene, 2018 - nature.com
Abstract Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism,
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …
[HTML][HTML] R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling
Summary R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
Differentiation therapy revisited
H de Thé - Nature Reviews Cancer, 2018 - nature.com
The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias,
and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell …
and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell …
[HTML][HTML] Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
IC Hvinden, T Cadoux-Hudson, CJ Schofield… - Cell Reports …, 2021 - cell.com
The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
The success and the challenge of all-trans retinoic acid in the treatment of cancer
X Ni, G Hu, X Cai - Critical reviews in food science and nutrition, 2019 - Taylor & Francis
All-trans retinoic acid (ATRA), an active metabolite of vitamin A, plays important roles in cell
proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA …
proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA …
The role of IDH mutations in acute myeloid leukemia
G Montalban-Bravo, CD DiNardo - Future Oncology, 2018 - Taylor & Francis
Isocitrate dehydrogenases (IDHs) are enzymes involved in multiple metabolic and
epigenetic cellular processes. Mutations in IDH1 or IDH2 are detected in approximately 20 …
epigenetic cellular processes. Mutations in IDH1 or IDH2 are detected in approximately 20 …
[HTML][HTML] Oxidative stress and hypoxia in normal and leukemic stem cells
U Testa, C Labbaye, G Castelli, E Pelosi - Experimental hematology, 2016 - Elsevier
The main hematopoietic stem cell (HSC) functions, self-renewal and differentiation, are
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …
[HTML][HTML] Classic and variants APLs, as viewed from a therapy response
MC Geoffroy, H de Thé - Cancers, 2020 - mdpi.com
Most acute promyelocytic leukemia (APL) are caused by PML-RARA, a translocation-driven
fusion oncoprotein discovered three decades ago. Over the years, several other types of …
fusion oncoprotein discovered three decades ago. Over the years, several other types of …