Adverse drug reactions (ADRs) represent a major health problem worldwide, with high
morbidity and mortality rates. ADRs are classified into Type A (augmented) and Type B …

ContextAlthough acetylsalicylic acid (aspirin) is commonly used for patients with chronic
cardiovascular disease, a minority of patients have a sensitivity to acetylsalicylic acid and …

Paracetamol is recommended as first-line therapy for pain associated with osteoarthrosis
and is one of the most widely used over-the-counter analgesic drugs worldwide. Despite its …

The correlation between aspirin sensitivity, asthma, and nasal polyposis was recognized in
the early 20th century. Today, this classic triad of symptoms, eponymously named Samter's …

Background The prevalence and mean provocative dose of oral aspirin (MPDA) triggering
respiratory reactions in people with asthma have been inconsistently reported, and the …

We conducted a retrospective study to determine the prevalence of Samter's triad (nasal
polyps, asthma, and aspirin sensitivity) in 208 consecutively presenting patients who had …

BACKGROUND: A definitive diagnosis of aspirin-exacerbated respiratory disease (AERD)
requires a positive oral aspirin challenge (OAC), but predicting which patients will have …

Cysteinyl leukotrienes (Cys-LTs) are potent proinflammatory mediators derived from
arachidonic acid through the 5-lypoxigenase (5-LO) pathway. They exert important …

Aspirin was introduced into medicine over a century ago and has become the most popular
drug in the world. Although the first hypersensitivity reaction was described soon after …

Rationale: Common cold and flu are the most common human illnesses, and over‐the‐
counter (OTC) analgesics are widely used to treat the pain and fever symptoms. Despite the …