5‐Hydroxytryptamine, or serotonin, is a biogenic amine most noted for its role as a
neurotransmitter. Manipulation of serotonin in animal models was used as a tool for studying …

Over the past decade, a variety of serotonin (5-hydroxytryptamine, 5-HT) receptor/binding
sites have been identified. These include 5-HT 1, 5-HT 2, and 5-HT 3 sites. The 5-HT 1 sites …

Objective: Accumulated neurochemical data in different animal models of fulminant hepatic
failure and in humans with hepatic encephalopathy suggest that serotoninergic tone is …

Ketanserin is an agent whose main pharmacologic action is antagonism of serotonin (5-
hydroxytryptamine, 5HT) receptors of the 5HT2 subtype. It also has weak α1-adrenergic …

The cardiovascular effects of 5‐hydroxytryptamine (5‐HT), consisting of bradycardia or
tachycardia, hypotension or hypertension, and vasodilatation or vasoconstriction, are …

1 A study was made of the effects of 5‐hydroxytryptamine (5‐HT) on pressor response
induced in vivo by electrical stimulation of the sympathetic outflow from the spinal cord of …

Feeding a vitamin B 6-deficient diet to rats causes a moderate hypertension. The blood
pressure responses to 5-HT 1A receptor agonists were studied in conscious vitamin B 6 …

G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTK) modulate vascular
tone and contraction via rapid and long-term processes. Sustained activation of these …

Hypertension, the sustained elevation of systemic arterial pressure with a systolic pressure
over 160 mm Hg and a diastolic pressure greater than 95 mm Hg, is one of the major causes …

The 5-HT 2 antagonist ketanserin inhibited salt appetite induced by subchronic
deoxycorticosterone acetate (DOCA) treatment, as well as salt induced by sodium depletion …