During the last decade, experimental and clinical studies have demonstrated that isolated
acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and …

Stroke is one of the leading causes of death and disability worldwide. Stroke recovery is
orchestrated by a set of highly interactive processes that involve the neurovascular unit and …

Background—Although lymphocyte recruitment and activation are associated with cerebral
ischemia-reperfusion (I/R) injury, the contributions of specific lymphocyte subpopulations …

Acute AMPK activation exacerbates ischemic brain damage experimentally. Paradoxically,
the clinical use of an AMPK activator metformin reduces the incidence of stroke. We …

Systemic immunosuppression has been associated with stroke for many years, but the
underlying mechanisms are poorly understood. In this study, we demonstrated that stroke …

Background Infection after surgery and trauma is a major cause of increased morbidity,
mortality, and cost. Alterations of the hosts immune system following these insults is believed …

The concept of 'Compensatory anti-inflammatory response syndrome'(CARS) was proposed
in 1997 by Roger Bone (1941–1997) to qualify the consequences of the counter-regulatory …

Growing evidences suggest that stroke is a systemic disease affecting many organ systems
beyond the brain. Stroke-related systemic inflammatory response and immune …

Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

Importance Pronounced inflammatory reactions occurring shortly after intracerebral
hemorrhage (ICH) contribute to the formation and progression of perihematomal edema …