In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Nickel compounds are environmental toxicants, prevalent in the atmosphere due to their
widespread use in several industrial processes, extensive consumption of nickel containing …

Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively
expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of
the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) is involved in …

Armeniacae semen amarum—seeds of Prunus armeniaca L.(Rosaceae)(ASA), also known
as Kuxingren in Chinese, is a traditional Chinese herbal drug commonly used for lung …

The ability of human tissue to reorganize and restore its existing structure underlies tissue
homeostasis in the healthy airways, but in disease can persist without normal resolution …

Background Rhinovirus infections commonly evoke asthma exacerbations in children and
adults. Recurrent asthma exacerbations are associated with injury-repair responses in the …

Bronchial asthma is a common chronic airway disease, and long-term management of
asthma is the focus and challenge of clinical treatment. Glucocorticoids are often used as the …

Interleukin-33 (IL-33) belongs to the interleukin-1 (IL-1) family, and its structure is similar to
IL-18. When cells are damaged or undergo necrosis, mature form of IL-33 is secreted as a …