The development of reversibly binding radioligands for imaging brain proteins in vivo, such
as enzymes, neurotransmitter transporters, receptors and ion channels, with positron …

The serotonergic system plays a key modulatory role in the brain and is the target for many
drug treatments for brain disorders either through reuptake blockade or via interactions at …

Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …

Abstract Objective People with Parkinson disease (PD) frequently develop dementia, which
is associated with neocortical deposition of alpha‐synuclein (α‐syn) in Lewy bodies and …

The serotonergic system is one of the most important modulatory neurotransmitter systems
in the human brain. It plays a central role in major physiological processes and is implicated …

With the emergence of positron emission tomography (PET) in the late 1970s, psychiatry
had access to a tool capable of non‐invasive assessment of human brain function. Early …

Neuronal circuits in the brain that utilize the neurotransmitter serotonin are essential to the
regulation of mood and emotional expression. Disruptions in serotonin signaling underlie …

Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major
depression. However, the link between inhibition of serotonin reuptake and remission from …

Serotonin (5-hydroxytryptamine, 5-HT) and 5-HT receptors (5-HTRs) have crucial roles in
various neuropsychiatric disorders and neurodegenerative diseases, making them attractive …

Reuptake of neurotransmitters from the brain interstitium shapes chemical signaling
processes and is disrupted in several pathologies. Serotonin reuptake in particular is …