From genome to drugs: new approaches in antimicrobial discovery

F Serral, FA Castello, EJ Sosa, AM Pardo… - Frontiers in …, 2021 - frontiersin.org
Decades of successful use of antibiotics is currently challenged by the emergence of
increasingly resistant bacterial strains. Novel drugs are urgently required but, in a scenario …

A journey through the Corynebacterium pseudotuberculosis proteome promotes insights into its functional genome

WM da Silva, N Seyffert, A Silva, V Azevedo - PeerJ, 2021 - peerj.com
Background Corynebacterium pseudotuberculosis is a Gram-positive facultative intracellular
pathogen and the etiologic agent of illnesses like caseous lymphadenitis in small ruminants …

An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets

PIP Ramos, D Fernández Do Porto, E Lanzarotti… - Scientific reports, 2018 - nature.com
Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can
cause life-threatening infections. It has been found as the culprit of many infection outbreaks …

[HTML][HTML] Prediction of new vaccine targets in the core genome of Corynebacterium pseudotuberculosis through omics approaches and reverse vaccinology

CL Araújo, J Alves, W Nogueira, LC Pereira… - Gene, 2019 - Elsevier
Corynebacterium pseudotuberculosis is the etiologic agent of veterinary relevance
diseases, such as caseous lymphadenitis, affecting different animal species causing …

PBIT: pipeline builder for identification of drug targets for infectious diseases

G Shende, H Haldankar, RS Barai, MH Bharmal… - …, 2017 - academic.oup.com
Abstract Summary PBIT (Pipeline Builder for Identification of drug Targets) is an online
webserver that has been developed for screening of microbial proteomes for critical features …

Exploring and targeting potential druggable antimicrobial resistance targets ArgS, SecY, and MurA in Staphylococcus sciuri with TCM inhibitors through a subtractive …

A Khan, S Sohail, S Yaseen, S Fatima, A Wisal… - Functional & Integrative …, 2023 - Springer
Staphylococcus sciuri (also currently Mammaliicoccus sciuri) are anaerobic facultative and
non-motile bacteria that cause significant human pathogenesis such as endocarditis, wound …

Subtractive sequence analysis aided druggable targets mining in Burkholderia cepacia complex and finding inhibitors through bioinformatics approach

SS Hassan, R Shams, I Camps, Z Basharat, S Sohail… - Molecular Diversity, 2023 - Springer
Burkholderia cepacia complex (BCC) is a group of gram-negative bacteria composed of at
least 20 different species that cause diseases in plants, animals as well as humans (cystic …

Recombinant esterase from Corynebacterium pseudotuberculosis in DNA and subunit recombinant vaccines partially protects mice against challenge

AA Brum, AFS Rezende… - Journal of medical …, 2017 - microbiologyresearch.org
Purpose. We tested the efficacy of the esterase encoded by cp1002_RS09720 from
Corynebacterium pseudotuberculosis in recombinant subunit and DNA caseous …

Delineating Novel Therapeutic Drug and Vaccine Targets for Staphylococcus cornubiensis NW1T Through Computational Analysis

M Shah, S Jaan, B Fatima, MS Javed, A Amjad… - International Journal of …, 2021 - Springer
Staphylococcal multidrug resistance is an emerging future threat. Among staphylococci
species, Staphylococcus intermedius group (SIG) comprises of coagulase-positive four …

The Druggable Pocketome of Corynebacterium diphtheriae: A New Approach for in silico Putative Druggable Targets

SS Hassan, SB Jamal, LG Radusky, S Tiwari… - Frontiers in …, 2018 - frontiersin.org
Diphtheria is an acute and highly infectious disease, previously regarded as endemic in
nature but vaccine-preventable, is caused by Corynebacterium diphtheriae (Cd). In this …