Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CM) have been
intensively used in drug development and disease modeling. Since iPSC-cardiomyocyte …

In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …

In biointegrated electronics, the facile control of mechanical properties such as softness and
stretchability in electronic devices is necessary to minimize the perturbation of motions …

Contractility of the myocardium engines the pumping function of the heart and is enabled by
the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on …

Matrix nanotopographical cues are known to regulate the structure and function of somatic
cells derived from human pluripotent stem cell (hPSC) sources. High-throughput …

Recent advances in cardiac tissue engineering have shown that human induced-pluripotent
stem cell-derived cardiomyocytes (hiPSC-CMs) cultured in a three-dimensional (3D) micro …

Introduction Voltage-sensitive optical (VSO) sensors offer a minimally invasive method to
study the time course of repolarization of the cardiac action potential (AP). This …

Background Cardiac arrhythmias have markedly increased in recent decades, highlighting
the urgent need for appropriate test systems to evaluate the efficacy and safety of new …

Abstract Development of novel testing strategies to detect adverse human health effects is of
interest to replace in vivo-based drug and chemical safety testing. The aim of the present …

Cardiotoxicity is an important toxicological endpoint for chemical and drug safety
assessment. The present study aims to evaluate two stemcell-based in vitro models for …