Tetrahydrobipterin (BH4) is a pivotal enzymatic cofactor required for the synthesis of
serotonin, dopamine and nitric oxide. BH4 is essential for numerous physiological …

Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes.
These conditions synergistically increase the risk of cardiovascular events. A number of …

Objective We investigated the effects of high-fat diet-induced obesity on vascular
proinflammatory factors and oxidative stress on endothelium-dependent relaxation of the …

Patients with diabetes mellitus (DM) have a high prevalence of coronary artery disease
(CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Endothelial …

The endothelium plays a vital role in maintaining circulatory homeostasis by the release of
relaxing and contracting factors. Any change in this balance may result in a process known …

Aims Hypertension is associated with increased levels of circulating cytokines and recent
studies have shown that innate immunity contributes to hypertension. The mechanisms …

BACKGROUND: Animal experimentation has a long tradition in diabetes research and has
provided invaluable benefits with regard to insulin discovery and treatment assessment …

Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO
bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads …

Gender plays a pivotal role in the onset as well as in the progression of the cardiovascular
disease with a higher morbidity and mortality being detected in men with respect to women …

Background and aim given that obesity is an independent risk factor for the development of
cardiovascular diseases we decided to investigate the mechanisms involved in …