Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention

P Garg, M Markl, J Sathananthan, SL Sellers… - Nature Reviews …, 2024 - nature.com
Aortic blood flow patterns are closely linked to the morphology and function of the left
ventricle, aortic valve and aorta. These flow patterns demonstrate the exceptional …

Impact of calcific aortic valve disease on valve mechanics

BJ Vogl, NR Niemi, LG Griffiths, MA Alkhouli… - … and modeling in …, 2022 - Springer
The aortic valve is a highly dynamic structure characterized by a transvalvular flow that is
unsteady, pulsatile, and characterized by episodes of forward and reverse flow patterns …

Predictive model for thrombus formation after transcatheter valve replacement

H Hatoum, S Singh-Gryzbon, F Esmailie… - Cardiovascular …, 2021 - Springer
Purpose Leaflet thrombosis is a significant adverse event after transcatheter aortic valve
(TAV) replacement (TAVR). The purpose of our study was to present a semi-empirical …

Sinus hemodynamics variation with tilted transcatheter aortic valve deployments

H Hatoum, J Dollery, SM Lilly, JA Crestanello… - Annals of biomedical …, 2019 - Springer
Leaflet thrombosis is a complication associated with transcatheter aortic valve (TAV)
replacement (TAVR) correlated with sinus flow stasis. Sinus hemodynamics are important …

[HTML][HTML] Modeling risk of coronary obstruction during transcatheter aortic valve replacement

M Heitkemper, H Hatoum, A Azimian, B Yeats… - The Journal of thoracic …, 2020 - Elsevier
Objective In this study we aimed to evaluate risk of coronary obstruction during transcatheter
aortic valve replacement and develop improved criteria based on computational modeling …

Differences in pressure recovery between balloon expandable and self-expandable transcatheter aortic valves

H Hatoum, RT Hahn, S Lilly, LP Dasi - Annals of biomedical engineering, 2020 - Springer
Pressure recovery downstream of the aortic valve constitutes an important factor affecting
the calculation of pressure gradient (PG) across the valve and therefore the accuracy of the …

Fluid structure interaction modelling of aortic valve stenosis: effects of valve calcification on coronary artery flow and aortic root hemodynamics

AR Kivi, N Sedaghatizadeh, BS Cazzolato… - Computer Methods and …, 2020 - Elsevier
Background and objective Coronary artery diseases and aortic valve stenosis are two of the
main causes of mortality and morbidity worldwide. Stenosis of the aortic valve develops due …

[HTML][HTML] The hemodynamics of transcatheter aortic valves in transcatheter aortic valves

H Hatoum, S Lilly, P Maureira, J Crestanello… - The Journal of thoracic …, 2021 - Elsevier
Background The durability of transcatheter aortic valves (TAVs) remains their greatest
disadvantage, given that fixed tissue leaflets are not immune to structural degeneration from …

Sinus hemodynamics in representative stenotic native bicuspid and tricuspid aortic valves: an in-vitro study

H Hatoum, LP Dasi - Fluids, 2018 - mdpi.com
(1) The study's objective is to assess sinus hemodynamics differences between stenotic
native bicuspid aortic valve (BAV) and native tricuspid aortic valve (TrAV) sinuses in order to …

Reduction of pressure gradient and turbulence using vortex generators in prosthetic heart valves

H Hatoum, LP Dasi - Annals of biomedical engineering, 2019 - Springer
Blood damage and platelet activation are inherent problems with present day bi-leaflet
mechanical heart valve designs. Passive flow control through different arrangements of …