Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Fat and carbohydrate are important fuels for aerobic exercise and there can be reciprocal
shifts in the proportions of carbohydrate and fat that are oxidized. The interaction between …

Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in
response to disruptions to cellular homeostasis. The process of exerciseinduced adaptation …

Endurance exercise training induces mitochondrial biogenesis in skeletal muscle. The
peroxisome proliferator activated receptor co‐activator 1α (PGC‐1α) has recently been …

AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a …

Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative
stress that contributes to the pathogenesis of this debilitating disease. This has prompted …

Physical activity relies on muscular force. In adult skeletal muscle, force results from the
contraction of postmitotic, multinucleated myofibres of different contractile and metabolic …

A hypothesis is presented based on a coalescence of anthropological estimations of Homo
sapiens' phenotypes in the Late Paleolithic era 10,000 years ago, with Darwinian natural …

Endurance exercise induces a variety of metabolic and morphological
responses/adaptations in skeletal muscle that function to minimize cellular disturbances …

Tumor metabolism consists of complex interactions between oxygenation states,
metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate …