Sex disparity in gastric cancer: female sex is a poor prognostic factor for advanced gastric cancer

HW Kim, JH Kim, BJ Lim, HK Kim, H Kim… - Annals of surgical …, 2016 - Springer
Background The overall incidence of gastric cancer (GC) is higher in males than females.
Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female …

Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women

ND Freedman, WH Chow, YT Gao, XO Shu, BT Ji… - Gut, 2007 - gut.bmj.com
Background: Gastric cancer incidence rates are consistently lower in women than men in
both high and low-risk regions worldwide. Sex hormones, such as progesterone and …

Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation

JT Busada, KN Peterson, S Khadka, X Xu, RH Oakley… - Gastroenterology, 2021 - Elsevier
Background & Aims The immune compartment is critical for maintaining tissue homeostasis.
A weak immune response increases susceptibility to infection, but immune hyperactivation …

[HTML][HTML] The androgen receptor expression and association with patient's survival in different cancers

C Hu, D Fang, H Xu, Q Wang, H Xia - Genomics, 2020 - Elsevier
To understand the androgen receptor (AR) in different human malignancies, we conducted a
pan-cancer analysis of AR in different tumor tissues and association with patient survival …

[HTML][HTML] Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer

W Tang, R Liu, Y Yan, X Pan, M Wang, X Han, H Ren… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Despite the mounting studies exploring the role of estrogen receptor alpha (ERα), estrogen
receptor beta (ERβ) and androgen receptor (AR) in gastric cancer (GC), there remain …

Long noncoding RNA PART1 restrains aggressive gastric cancer through the epigenetic silencing of PDGFB via the PLZF-mediated recruitment of EZH2

H Han, S Wang, J Meng, G Lyu, G Ding, Y Hu, L Wang… - Oncogene, 2020 - nature.com
Current reports refer to the role of long noncoding RNA (lncRNA) prostate androgen-
regulated transcript 1 (PART1) as a tumor suppressor in some types of cancer but as an …

[HTML][HTML] Expression profile and prognostic role of sex hormone receptors in gastric cancer

L Gan, J He, X Zhang, YJ Zhang, GZ Yu, Y Chen, J Pan… - BMC cancer, 2012 - Springer
Background Increasing interest has been devoted to the expression and possible role of sex
hormone receptors in gastric cancer, but most of these findings are controversial. In the …

[HTML][HTML] Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9

B Zhang, T Du, Q Chang, Z Fan, J Li, B Yu, L Su, C Li… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Androgen receptor (AR) plays an important role in many kinds of cancers. However, the
molecular mechanisms of AR in gastric cancer (GC) are poorly characterized. Here, we …

Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients

SJ Noh, MJ Kang, KM Kim, JS Bae, HS Park, WS Moon… - Pathology, 2013 - Elsevier
Aims Recently, the important role of silent mating type information regulation 2 homolog 1
(SIRT1) and deleted in breast cancer 1 (DBC1) in human cancer has been extensively …

CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer

Y Su, Y Lin, L Zhang, B Liu, W Yuan, X Mo… - Cancer …, 2014 - Wiley Online Library
The CKLF‐like MARVEL transmembrane domain containing 3 (CMTM 3) gene is a novel
tumor suppressor with frequent epigenetic inactivation. In this study, we showed the role …