Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

Non-alcoholic fatty liver disease (NAFLD) is an important public health problem with growing
numbers of NAFLD patients worldwide. Pathological conditions are different in each stage of …

Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires
the cell-surface protein NINJ1. PMR releases pro-inflammatory cytoplasmic molecules …

Abstract Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major
complication of liver transplantation. Transmembrane member 16A (TMEM16A), a …

Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver resection or liver
transplantation that can seriously affect patient's prognosis. There is currently no definitive …

Ferroptosis has been linked to the pathogenesis of hepatic injury induced by
ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by …

Neutrophils and platelets are among the most abundant cell types in peripheral blood and
characterized by high plasticity and a readily available reservoir of surface proteins and …

Ferroptosis, a newly characterized form of regulated cell death, is induced by excessive
accumulation of lipid peroxidation catalyzed by intracellular bioactive iron. Increasing …

Hepatic ischemia-reperfusion (I/R) injury, a common clinical complication of liver
transplantation, gravely affects patient prognosis. Krüppel-like factors (KLFs) constitute a …

Neutrophils, the largest innate immune cell population in humans, are the primary
proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic …