Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver resection or liver
transplantation that can seriously affect patient's prognosis. There is currently no definitive …

Neutrophils, the largest innate immune cell population in humans, are the primary
proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic …

Reactive oxygen species (ROS) are important second messengers in many metabolic
processes and signaling pathways. Disruption of the balance between ROS generation and …

Depression is a frequent symptom in patients with chronic liver disease; however, the
mechanisms underlying this association remain unclear. Dysbiosis of gut microbiota plays a …

Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …

Copper (Cu) is a vital trace element for maintaining human health. Current evidence
suggests that genes responsible for regulating copper influx and detoxification help …

Rationale: Liver resection and transplantation surgeries are accompanied by hepatic
ischemia-reperfusion (HIR) injury that hampers the subsequent liver recovery. Given that the …

Non-alcoholic fatty liver disease (NAFLD) is an important public health problem with growing
numbers of NAFLD patients worldwide. Pathological conditions are different in each stage of …

Abstract Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to
inflammatory, metabolic, and oxidative stressors. We previously reported that myeloid SIRT1 …