Abstract Background & Aims Persistent cholestasis has been associated with poor
prognosis after orthotopic liver transplantation (OLT). In this study, we aimed to investigate …

Hepatic ischemia-reperfusion injury (HIRI) remains to be an unsolved risk factor that
contributes to organ failure after liver surgery. Our clinical retrospective study showed that …

Pannexin1 proteins form communication channels at the cell plasma membrane surface,
which allow the transfer of small molecules and ions between the intracellular compartment …

Machine perfusion is an emerging technology in the field of liver transplantation. While
machine perfusion has now been implemented in clinical routine throughout transplant …

Background Hepatic ischemia–reperfusion (IR) injury is a major complication of liver
transplantation and gravely affects patient prognosis. Icaritin (ICT), the primary plasma …

Background & Aims Hepatic ischemia-reperfusion injury (HIRI) often occurs in liver surgery,
such as partial hepatectomy and liver transplantation, in which myeloid macrophage …

Severe steatosis in donor livers is contraindicated for transplantation due to the high risk of
ischemia–reperfusion injury (IRI). Although Ho-1 gene-modified bone marrow mesenchymal …

Liver ischemia-reperfusion injury (LIRI) can occur during liver resection, liver transplantation,
shock, and other hemorrhagic conditions, resulting in profound local and systemic effects via …

Hepatic ischemia–reperfusion (I/R) injury is still a major risk factor and unsolved problem in
hepatic surgery. Methyltransferase-like 3 (METTL3), an important m6A-modified methylase …

Pyroptosis, a programmed cell death marked by lytic and inflammatory characteristics, plays
a crucial role in non‑infectious inflammation‑related diseases but can lead to detrimental …