Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension
Introduction Type II diabetes mellitus (T2DM) is a metabolic disorder that poses a serious
health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent …
health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent …
Mitochondrial biomarkers for airborne particulate matter associated cardiovascular diseases
PK Mishra, P Kaur - Current Opinion in Environmental Science & Health, 2023 - Elsevier
Airborne particulate matter pollution has become a significant global health concern due to
its detrimental effects on human health, including cardiovascular diseases (CVDs) …
its detrimental effects on human health, including cardiovascular diseases (CVDs) …
Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant …
C Zhuo, J Xin, W Huang, D Zhang, X Yan, R Li, H Li… - Toxicology, 2023 - Elsevier
Irisin, a new exercise-mediated myokine, plays an important role in cardiovascular diseases
by regulating cell energy metabolism. The induction of mitochondrial dysfunction and …
by regulating cell energy metabolism. The induction of mitochondrial dysfunction and …
The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice
A Reis-Mendes, M Ferreira, JA Duarte… - Archives of …, 2023 - Springer
Doxorubicin (DOX) is a potent chemotherapeutic agent used against several cancer types.
However, due to its cardiotoxic adverse effects, the use of this drug may be also life …
However, due to its cardiotoxic adverse effects, the use of this drug may be also life …
Toll-like receptor 4 inflammatory perspective on doxorubicin-induced cardiotoxicity
Doxorubicin (Dox) is one of the most frequently used chemotherapeutic drugs in a variety of
cancers, but Dox-induced cardiotoxicity diminishes its therapeutic efficacy. The underlying …
cancers, but Dox-induced cardiotoxicity diminishes its therapeutic efficacy. The underlying …
Tumor-targeted and stimulus-responsive polymeric prodrug nanoparticles to enhance the anticancer therapeutic efficacy of doxorubicin
N Kim, S Kwon, G Kwon, N Song, H Jo, C Kim… - Journal of Controlled …, 2024 - Elsevier
Polymeric prodrug nanoparticles have gained increasing attention in the field of anticancer
drug delivery because of their dual functions as a drug carrier and a therapeutic agent …
drug delivery because of their dual functions as a drug carrier and a therapeutic agent …
Approaches for reducing chemo/radiation-induced cardiotoxicity by nanoparticles
K Li, W Chen, L Ma, L Yan, B Wang - Environmental Research, 2023 - Elsevier
Nanoparticles are fascinating and encouraging carriers for cancer treatment due to their
extraordinary properties and potential applications in targeted drug delivery, treatment, and …
extraordinary properties and potential applications in targeted drug delivery, treatment, and …
The Cardioprotective and Anticancer Effects of SGLT2 Inhibitors: JACC: CardioOncology State-of-the-Art Review
Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally approved for type 2
diabetes mellitus, have demonstrated efficacy in reducing cardiovascular events, particularly …
diabetes mellitus, have demonstrated efficacy in reducing cardiovascular events, particularly …
Doxorubicin Dose-Dependent Impact on Physiological Balance—A Holistic Approach in a Rat Model
AI Afonso, Â Amaro-Leal, F Machado, I Rocha… - Biology, 2023 - mdpi.com
Simple Summary This study investigated how different doses of the chemotherapeutic drug
doxorubicin affected physiological parameters and autonomic function in rats. A positive …
doxorubicin affected physiological parameters and autonomic function in rats. A positive …
Simvastatin Reduces Doxorubicin-Induced Cardiotoxicity: Effects beyond Its Antioxidant Activity
M Pecoraro, S Marzocco, R Belvedere… - International Journal of …, 2023 - mdpi.com
This study aimed to evaluate if Simvastatin can reduce, and/or prevent, Doxorubicin (Doxo)-
induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then …
induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then …