[HTML][HTML] Forty years since the structural elucidation of platelet-activating factor (PAF): historical, current, and future research perspectives

R Lordan, A Tsoupras, I Zabetakis, CA Demopoulos - Molecules, 2019 - mdpi.com
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Targeting cellular cholesterol for anticancer therapy

L Gu, ST Saha, J Thomas, M Kaur - The FEBS journal, 2019 - Wiley Online Library
Cholesterol dyshomeostasis in cancer cells leads to intracellular cholesterol accumulation,
which imparts drug resistance and allows these cells to evade apoptotic signalling …

[HTML][HTML] Atorvastatin can modulate DNA damage repair in endothelial cells exposed to mitomycin C

M Sinitsky, M Asanov, A Sinitskaya… - International Journal of …, 2023 - mdpi.com
HMG-CoA reductase inhibitors (statins) are widely used in the therapy of atherosclerosis
and have a number of pleiotropic effects, including DNA repair regulation. We studied the …

[HTML][HTML] Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice

M Ramchoun, T Khouya, H Harnafi, C Alem… - Future journal of …, 2020 - Springer
Background Thymus atlanticus is an endemic plant of the Mediterranean region, which has
been used in the Moroccan mountain area to treat several diseases. This study aimed to …

Effect of Aqueous Extract and Polyphenol Fraction Derived from Thymus atlanticus Leaves on Acute Hyperlipidemia in the Syrian Golden Hamsters

M Ramchoun, T Khouya, H Harnafi… - Evidence‐Based …, 2020 - Wiley Online Library
Thymus atlanticus, an endemic plant of Morocco, is traditionally used as a liniment or a drink
to treat various diseases. However, there are few available scientific data regarding its …

Microbial oil, alone or paired with β-glucans, can control hypercholesterolemia in a zebrafish model

AH Gora, S Rehman, J Dias, JMO Fernandes… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Dyslipidemia is often associated with unhealthy dietary habits, and many mammalian
studies have explored the mode of action of certain bioactive compounds such as β-glucans …

One Molecule, Many Faces: Repositioning Cardiovascular Agents for Advanced Wound Healing

A Gościniak, A Stasiłowicz-Krzemień, B Michniak-Kohn… - Molecules, 2024 - mdpi.com
Chronic wound treatments pose a challenge for healthcare worldwide, particularly for the
people in developed countries. Chronic wounds significantly impair quality of life, especially …

[HTML][HTML] Phytochemical analysis and bioactivity evaluation of Moroccan Thymus atlanticus (Ball) fractions

T Khouya, M Ramchoun, A Hmidani, S Amrani, C Alem - Scientific African, 2021 - Elsevier
This study aims to evaluate the effect of polar and less polar fractions of Thymus atlanticus
(T. atlanticus) on inflammation and hyperlipidemia in animal models, and on coagulation …

[HTML][HTML] Oroxin A from Oroxylum indicum improves disordered lipid metabolism by inhibiting SREBPs in oleic acid-induced HepG2 cells and high-fat diet-fed non …

T Cai, X Xu, L Dong, S Liang, M Xin, T Wang, T Li… - Heliyon, 2024 - cell.com
Background Lipid metabolism disorders have become a major global public health issue.
Due to the complexity of these diseases, additional research and drugs are needed. Oroxin …

Bioactive Metabolites from Fungi with Anti-Inflammatory and Antithrombotic Properties: Current Status and Future Perspectives for Drug Development

A Tsoupras, KG Davi - Fungi Bioactive Metabolites: Integration of …, 2024 - Springer
Bioactives of natural origin have recently gained a lot of ground in drug discovery due to
their enormous structural diversity, diverse pharmacological activities, safety, and inherent …