Fibronectin, a dimeric cell-adhesive extracellular matrix glycoprotein, is secreted by
mesenchymal cells and assembled into insoluble matrices which have important biological …

Diurnal-nocturnal, or circadian-like, rhythms are 24-h variations in biological processes,
evolved for the efficient functioning of living organisms. Such oscillations and their regulation …

Macrophages are thought to play an important role in the pathologic changes associated
with idiopathic pulmonary fibrosis (IPF). The mechanisms for increased monocyte …

Lung injury triggers an acute inflammatory response characterized by increased expression
and deposition of extracellular matrix (ECM) components such as fibronectin and collagen …

The deleterious effects of ozone (O3), an oxidant air pollutant, in the lung are dependent on
dose and exposure duration and generally evolve with time postexposure. This study …

This study investigated the relationship of fibronectin expression and induction of pulmonary
inflammation by ozone (O3). Rats were exposed to 0.8 parts/million O3 to induce lung …

CURRICULUM VITAE Page 1 CURRICULUM VITAE May 1, 2024 JESSE ROMAN, MD, ATSF,
FACCP, FACP, FSSCI Ludwig Kind Professor of Medicine Professor, Pharmacology & …

Tissue response to injury entails the activation of repair mechanisms that promote removal
of debris, granulation tissue formation, and tissue reorganization. This wound healing …

Intact fetal hamster lungs were taken for culture on gestational day 12, when only lobar
bronchi and primary bronchioles are established and the epithelial cells are undifferentiated …

The biologic impact of consecutive exposures to two environmental pollutants was
examined in mice exposed to silica crystals (SI) by intratracheal (IT) injection followed by an …