A tale of two diseases: Exploring mechanisms linking diabetes mellitus with Alzheimer's disease
J Lynn, M Park, C Ogunwale… - Journal of …, 2022 - content.iospress.com
Dementias, including the type associated with Alzheimer's disease (AD), are on the rise
worldwide. Similarly, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic …
worldwide. Similarly, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic …
Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism
Y Wang, H Hu, X Liu, X Guo - Frontiers in Pharmacology, 2023 - frontiersin.org
Alzheimer's Disease (AD) is a global chronic disease in adults with beta-amyloid (Aβ)
deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although …
deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although …
[HTML][HTML] The cause of Alzheimer's disease: the theory of multipathology convergence to chronic neuronal stress
B Decourt, GX D'Souza, J Shi, A Ritter, J Suazo… - Aging and …, 2022 - ncbi.nlm.nih.gov
The field of Alzheimer's disease (AD) research critically lacks an all-inclusive etiology theory
that would integrate existing hypotheses and explain the heterogeneity of disease trajectory …
that would integrate existing hypotheses and explain the heterogeneity of disease trajectory …
The role of microRNA-34 family in Alzheimer's disease: A potential molecular link between neurodegeneration and metabolic disorders
Growing evidence indicates that overexpression of the microRNA-34 (miR-34) family in the
brain may play a crucial role in Alzheimer's disease (AD) pathogenesis by targeting and …
brain may play a crucial role in Alzheimer's disease (AD) pathogenesis by targeting and …
REGULATORY ROLES OF microRNAs IN MODULATING MITOCHONDRIAL DYNAMICS, AMYLOID BETA FIBRILLATION, MICROGLIAL ACTIVATION, AND …
M Sharma, AK Tanwar, PK Purohit, P Pal… - Neuroscience & …, 2024 - Elsevier
Alzheimer's Disease (AD) remains a formidable challenge due to its complex pathology,
notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling …
notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling …
Potential for ketotherapies as amyloid-regulating treatment in individuals at risk for Alzheimer's disease
MK Taylor, DK Sullivan, JE Keller, JM Burns… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
clinical decline in memory and other cognitive functions. A classic AD neuropathological …
clinical decline in memory and other cognitive functions. A classic AD neuropathological …
Saffron as a promising therapy for diabetes and Alzheimer's disease: mechanistic insights
S Sanaie, S Nikanfar, ZY Kalekhane… - Metabolic Brain …, 2023 - Springer
The prevalence of both Alzheimer's disease (AD) and diabetes mellitus is increasing with
the societies' aging and has become an essential social concern worldwide. Accumulation …
the societies' aging and has become an essential social concern worldwide. Accumulation …
[HTML][HTML] Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010
QR Lin, LQ Jia, M Lei, D Gao, N Zhang, L Sha… - Pharmacological …, 2024 - Elsevier
Diabetes, characterized as a well-known chronic metabolic syndrome, with its associated
complications pose a substantial and escalating health and healthcare challenge on a …
complications pose a substantial and escalating health and healthcare challenge on a …
Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances
MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21–22 nucleotides in
length, which are master gene regulators. These miRNAs bind to the mRNA's 3' …
length, which are master gene regulators. These miRNAs bind to the mRNA's 3' …
ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK-PPARα-CPT1A axis
J Dong, M Li, R Peng, Y Zhang, Z Qiao… - Journal of Translational …, 2024 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder,
whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the …
whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the …