Peptide and protein (P/P) drugs have been identified as showing great promises for the
treatment of various neurodegenerative diseases. A major challenge in this regard …

Gonadotropin-releasing hormone (GnRH) secretion has two modes of release in
mammalian species; the surge mode and the pulse mode. The surge mode, which is …

Gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain are the final
common pathway through which the brain regulates reproduction. GnRH secretion occurs in …

The first report demonstrating the therapeutic efficacy of an orally applied neurokinin-1
(NK1) receptor antagonist in depression was published 10 years ago. Although there were …

Although current antipsychotic drugs are effective at treating the psychotic (positive)
symptoms of schizophrenia, they have one or more serious side effects, including …

Neurons in the arcuate nucleus (ARC) that concomitantly express kisspeptin, neurokinin B
(NKB) and dynorphin A are termed KNDy neurons and are likely candidates for the intrinsic …

The activity of substantia nigra pars reticulata (SNr) neurons, the main output structure of
basal ganglia, is altered in Parkinson's disease (PD). However, neither the underlying …

Substance P (SP) and neurotensin (NT) are neuropeptides isolated in the periphery and in
the central nervous system. They are involved in various regulatory processes in the …

The aim of this work was to evaluate the capability of lactoferrin-and antitransferrin-modified
long circulating liposomes to deliver the hydrophilic peptide senktide, a selective NK3 …

The regulation of dopaminergic and cholinergic function by neurokinin-3 (NK3) receptor
activation was examined in vivo in urethane-anaesthetized guinea pigs with microdialysis …