Motivation The conventional methods to detect homologous protein pairs use the
comparison of protein sequences. But the sequences of two homologous proteins may …

The YgjD/Kae1 family (COG0533) has been on the top‐10 list of universally conserved
proteins of unknown function for over 5 years. It has been linked to DNA maintenance in …

Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …

The universal tRNA modification t 6 A is found at position 37 of nearly all tRNAs decoding
ANN codons. The absence of t 6 A 37 leads to severe growth defects in baker's yeast …

The universal N 6-threonylcarbamoyladenosine (t6A) modification occurs at position 37 of
tRNAs that decipher codons starting with adenosine. Mechanistically, t6A stabilizes …

The anticodon stem-loop (ASL) of transfer RNAs (tRNAs) drives decoding by interacting
directly with the mRNA through codon/anticodon pairing. Chemically complex nucleoside …

The tRNA modification field has a rich literature covering biochemical analysis going back
more than 40 years, but many of the corresponding genes were only identified in the last …

Threonylcarbamoyladenosine (t6 A) is a modified nucleoside universally conserved in t RNA
s in all three kingdoms of life. The recently discovered genes for t6 A synthesis, including tsa …

Reversible protein phosphorylation is the main mechanism of signal transduction that
enables cells to rapidly respond to environmental changes by controlling the functional …

Genes that are normally biased towards expression in the testis are often induced in tumor
cells. These gametogenic genes, known as cancer-testis antigens (CTAs), have been …