The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation
AD Brunner, M Thielert, C Vasilopoulou… - Molecular systems …, 2022 - embopress.org
Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in …
and deep sequencing. However, proteins are the main drivers of cellular function and in …
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
Y Hu, C Chen, X Tong, S Chen, X Hu, B Pan… - Cell death & …, 2021 - nature.com
Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
Compositional control of phase-separated cellular bodies
Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-
separated liquids organized by multivalent interactions among proteins and RNA molecules …
separated liquids organized by multivalent interactions among proteins and RNA molecules …
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
S Ramazi, A Allahverdi, J Zahiri - Journal of biosciences, 2020 - Springer
Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response
Faithful genome integrity maintenance plays an essential role in cell survival. Here, we
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …
identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA …
Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles
Extracellular vesicles (EVs) are released by cells into the extracellular milieu to facilitate
intercellular communication in both physiological and pathological condition. EVs contain …
intercellular communication in both physiological and pathological condition. EVs contain …
Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
Discovery of TAK-981, a first-in-class inhibitor of SUMO-activating enzyme for the treatment of cancer
SP Langston, S Grossman, D England… - Journal of medicinal …, 2021 - ACS Publications
SUMOylation is a reversible post-translational modification that regulates protein function
through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of …
through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of …