Integration of computational analysis and spatial transcriptomics in single-cell studies

R Wang, G Peng, PPL Tam… - Genomics, Proteomics & …, 2023 - academic.oup.com
Recent advances of single-cell transcriptomics technologies and allied computational
methodologies have revolutionized molecular cell biology. Meanwhile, pioneering …

Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging

V LaLone, A Aizenshtadt, J Goertz, FS Skottvoll… - Cell Reports …, 2023 - cell.com
Confocal Raman spectral imaging (RSI) enables high-content, label-free visualization of a
wide range of molecules in biological specimens without sample preparation. However …

Cell Therapy for Liver Diseases: From Hepatocyte Transplantation to Bioartificial Livers

X Yuan, Z Sun, J Wu, L Hui, L Zhang - Current Opinion in Biomedical …, 2024 - Elsevier
Liver cell therapy presents a promising alternative to liver transplantation for patients with
liver failure and hereditary liver diseases. However, its clinical implementation is limited …

CD47 and PD-L1 overexpression in proliferating human hepatocytes attenuated immune responses and ameliorated acute liver injury in mice

C Ma, H Cao, Z Sun, Q Deng, W Liu, Y Xin… - American Journal of …, 2023 - Elsevier
Hepatocyte transplantation has the potential to treat acute liver failure and correct liver-
based metabolic disorders. Proliferating human hepatocytes (ProliHHs) provide a large …

Assessment of Primary Human Liver Cancer Cells by Artificial Intelligence-Assisted Raman Spectroscopy

C Esposito, M Janneh, S Spaziani, V Calcagno… - Cells, 2023 - mdpi.com
We investigated the possibility of using Raman spectroscopy assisted by artificial
intelligence methods to identify liver cancer cells and distinguish them from their Non-Tumor …

Comparative Analysis Using Raman Spectroscopy of the Cellular Constituents of Lacticaseibacillus paracasei Zhang in a Normal and Viable but Nonculturable State

Q Bao, X Bo, L Chen, Y Ren, H Wang, LY Kwok, W Liu - Microorganisms, 2023 - mdpi.com
This study aimed to investigate the molecular composition of a viable but nonculturable
(VBNC) state of a probiotic strain, Lacticaseibacillus paracasei Zhang (L. paracasei Zhang) …

Applying machine learning for multi-individual Raman spectroscopic data to identify different stages of proliferating human hepatocytes

B Shen, C Ma, L Tang, Z Wu, Z Peng, G Pan, H Li - Iscience, 2024 - cell.com
Cell therapy using proliferating human hepatocytes (ProliHHs) is an effective treatment
approach for advanced liver diseases. However, rapid and accurate identification of high …

Label-Free, Noninvasive Bone Cell Classification by Hyperspectral Confocal Raman Microscopy

ZT Piontkowski, DC Hayes, A McDonald… - … & Biomedical Imaging, 2024 - ACS Publications
Characterizing and identifying cells in multicellular in vitro models remain a substantial
challenge. Here, we utilize hyperspectral confocal Raman microscopy and principal …