To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Cyclic nucleotide phosphodiesterases (PDEs) that specifically inactivate the intracellular
messengers cAMP and cGMP in a compartmentalized manner represent an important …

Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents,
both autonomic and somatic, and supraspinal influences from visual, olfactory, and …

The cyclic guanosine monophosphate (cGMP) signaling system is one of the most
prominent regulators of a variety of physiological and pathophysiological processes in many …

The most recently identified cyclic nucleotide phosphodiesterases, PDE10 and PDE11,
contain a tandem of so-called GAF domains in their N-terminal regulatory regions. In PDE2 …

The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …

Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat
erectile dysfunction, has been linked to an increased risk of melanoma. Here, we have …

In the past ten years, several chromosomal loci have been identified by genome-wide
association studies to influence the risk of coronary artery disease (CAD) and its risk factors …

Mutations in the gene encoding the catalytic subunit of the cone photoreceptor
phosphodiesterase (PDE6C) have been recently reported in patients with autosomal …