The uptake of metal–organic frameworks: a journey into the cell

E Linnane, S Haddad, F Melle, Z Mei… - Chemical Society …, 2022 - pubs.rsc.org
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …

Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

Size-controlled synthesis of porphyrinic metal–organic framework and functionalization for targeted photodynamic therapy

J Park, Q Jiang, D Feng, L Mao… - Journal of the American …, 2016 - ACS Publications
The understanding of nanomaterials for targeted cancer therapy is of great importance as
physical parameters of nanomaterials have been shown to be strong determinants that can …

Delivery materials for siRNA therapeutics

R Kanasty, JR Dorkin, A Vegas, D Anderson - Nature materials, 2013 - nature.com
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

M Srinivasarao, CV Galliford, PS Low - Nature reviews Drug discovery, 2015 - nature.com
Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

Site-specific antibody–drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development

P Agarwal, CR Bertozzi - Bioconjugate chemistry, 2015 - ACS Publications
Antibody–drug conjugates (ADCs) combine the specificity of antibodies with the potency of
small molecules to create targeted drugs. Despite the simplicity of this concept, generation of …

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

N Kamaly, Z Xiao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …

Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems

JC Kraft, JP Freeling, Z Wang, RJY Ho - Journal of pharmaceutical …, 2014 - Elsevier
Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid
nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The …

Chemical protein modification through cysteine

SB Gunnoo, A Madder - ChemBioChem, 2016 - Wiley Online Library
The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …