Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Therapeutic interventions in patients with prolonged disorders of consciousness

A Thibaut, N Schiff, J Giacino, S Laureys… - The Lancet …, 2019 - thelancet.com
The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

D Kondziella, A Bender, K Diserens… - European journal of …, 2020 - Wiley Online Library
Background and purpose Patients with acquired brain injury and acute or prolonged
disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions …

Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning

M Lee, LRD Sanz, A Barra, A Wolff… - Nature …, 2022 - nature.com
Consciousness can be defined by two components: arousal (wakefulness) and awareness
(subjective experience). However, neurophysiological consciousness metrics able to …

Robust EEG-based cross-site and cross-protocol classification of states of consciousness

DA Engemann, F Raimondo, JR King, B Rohaut… - Brain, 2018 - academic.oup.com
Determining the state of consciousness in patients with disorders of consciousness is a
challenging practical and theoretical problem. Recent findings suggest that multiple markers …

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group

A Comanducci, M Boly, J Claassen, M De Lucia… - Clinical …, 2020 - Elsevier
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the
instrumental evaluation of patients with disorders of consciousness (DoC). The past few …

Early detection of consciousness in patients with acute severe traumatic brain injury

BL Edlow, C Chatelle, CA Spencer, CJ Chu, YG Bodien… - Brain, 2017 - academic.oup.com
Abstract See Schiff (doi: 10.1093/awx209) for a scientific commentary on this article. Patients
with acute severe traumatic brain injury may recover consciousness before self-expression …

The repetition of behavioral assessments in diagnosis of disorders of consciousness

S Wannez, L Heine, M Thonnard… - Annals of …, 2017 - Wiley Online Library
Objective To determine whether repeated examinations using the Coma Recovery Scale‐
Revised (CRS‐R) have an impact on diagnostic accuracy of patients with disorders of …

Preservation of brain activity in unresponsive patients identifies MCS star

A Thibaut, R Panda, J Annen, LRD Sanz… - Annals of …, 2021 - Wiley Online Library
Objective Brain‐injured patients who are unresponsive at the bedside (ie, vegetative
state/unresponsive wakefulness syndrome–VS/UWS) may present brain activity similar to …

Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study

J Stender, O Gosseries, MA Bruno, V Charland-Verville… - The Lancet, 2014 - thelancet.com
Background Bedside clinical examinations can have high rates of misdiagnosis of
unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The …