The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …

Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic
byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the …

Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

A generalized mechanism for hormetic dose responses is proposed that is based on the
redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of …

An increasing body of evidence highlights the strong potential for a diet rich in fruit and
vegetables to delay, and often prevent, the onset of chronic diseases, including …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is
present in the species of the Brassicaceae, especially in broccoli sprouts. In this study, the …

Background: In developed countries, the extension of human life is increasingly
accompanied by a progressive increase in neurodegenerative diseases, most of which do …

Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it
was also found in seeds and mature plants, SFN is mainly present in sprouts of many …

Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated
with high morbidity and mortality, and few or no effective options are available for their …