Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …

Polylysine and materials that integrate lysine form promising drug delivery platforms. As a
cationic macromolecule, a polylysine polymer electrostatically interacts with cells and is …

Abstract Generations 5 and 6 (G5 and G6) poly (amidoamine)(PAMAM) dendrimers have
been shown to be highly efficient nonviral carriers in in vitro gene delivery. However, their …

The complex copolymer of hyperbranched polyethylenimine (PEI) with hydrophobic poly (γ-
benzyl l-glutamate) segment (PBLG) at their chain ends was synthesized. This water-soluble …

The combination of chemotherapy and gene therapy could induce the enhanced therapeutic
efficacy in the cancer therapy. To achieve this goal, a new mesoporous silica nanoparticles …

Brushed polymers composed of a backbone of poly (hydroxyethyl methacrylate)(pHEMA)
onto which poly (2-(dimethylamino) ethyl methacrylate) s (pDMAEMAs) was grafted via a …

Objectives A vast number of blinding diseases have genetic aetiologies and may be treated
by molecular based therapies such as antisense oligonucleotides or short interfering RNA …

Stimuli-responsive block copolymers are very appealing sys-tems due to their polymorphism
of morphologies in selective solvents (eg, micelles, star micelles, vesicles, tubules, and …

A major challenge in gene therapy is the development of effective gene delivery vectors with
low toxicity. In the present study, linear poly (ethylenimine)(lPEI) with low molecular weight …

Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many
issues generate by chemotherapy drugs, including unfavorable harm to healthy cells and …