A causal role was recently attributed to inflammation in many malignant diseases, including
breast cancer. The different inflammatory mediators that are involved in this disease include …

Abstract IL-2, IL-15, and IL-7 are cytokines that are critical for regulating lymphoid
homeostasis. These cytokines stimulate similar responses from lymphocytes in vitro, but play …

Chronic inflammation and presence of inflammatory cells, primarily macrophages, at tumor
sites are highly associated with specific malignancies. In these cases, the inflammatory …

Cancer is a multi-faceted disease comprising complex interactions between neoplastic and
normal cells. Over the past decade, there has been considerable progress in defining the …

NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells
(DCs) play important roles in activating NK cells. We now find that murine IL-15Rα-deficient …

Harnessing neutrophils for the eradication of cancer cells remains an attractive but still
controversial notion. In this study, we provide evidence that neutrophils are required to …

Interleukin 15 participates in the development of important immune antitumor mechanisms. It
activates CD8+ T cells, natural killer (NK) cells, NK T cells, and can promote the formation of …

IL-21 is an immune-stimulatory four α helix cytokine produced by activated T cells. To study
the in vivo antitumor activities of IL-21, TS/A murine mammary adenocarcinoma cells were …

Purpose Preclinical evidence suggests that natural killer cell (NK-cell) function and
myokines facilitate the protective effects of exercise for breast cancer prevention. Since …

Polymorphonuclear neutrophils (PMN) are the most abundant circulating immune cells and
represent the first line of immune defense against infection. This review of the biomedical …