Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
[HTML][HTML] Fabrication of active targeting lipid nanoparticles: Challenges and perspectives
Targeted drug and gene delivery is the key for precision therapy. Lipid nanoparticles as non-
viral vectors have attracted extensive attentions in treating a variety of diseases, such as …
viral vectors have attracted extensive attentions in treating a variety of diseases, such as …
Inverse cubic and hexagonal mesophase evolution within ionizable lipid nanoparticles correlates with mRNA transfection in macrophages
mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
Engineering dynamic and interactive biomaterials using material nanoarchitectonics for modulation of cellular behaviors
Biophysical cues of native extracellular matrix (ECM) can affect cellular behavior. Although
static properties of biomaterials have been widely explored, there is a growing interest in …
static properties of biomaterials have been widely explored, there is a growing interest in …
Stabilizing RNA nanovaccines with transformable hyaluronan dynamic hydrogel for durable cancer immunotherapy
Massage RNA (mRNA) vaccines represent a new strategy for advanced cancer
immunotherapy. To protect mRNA from degradation and deliver to targeted cells, lipid …
immunotherapy. To protect mRNA from degradation and deliver to targeted cells, lipid …
Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy
Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …
Process robustness in lipid nanoparticle production: a comparison of microfluidic and turbulent jet mixing
MN O'Brien Laramy, AP Costa, YM Cebrero… - Molecular …, 2023 - ACS Publications
The recent clinical and commercial success of lipid nanoparticles (LNPs) for nucleic acid
delivery has incentivized the development of new technologies to manufacture LNPs. As …
delivery has incentivized the development of new technologies to manufacture LNPs. As …
mRNA nanodelivery systems: targeting strategies and administration routes
M Yuan, Z Han, Y Liang, Y Sun, B He… - Biomaterials …, 2023 - spj.science.org
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …
A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient
With the recent success of lipid nanoparticle (LNP) based SARS-CoV-2 mRNA vaccines, the
potential for RNA therapeutics has gained widespread attention. LNPs are promising non …
potential for RNA therapeutics has gained widespread attention. LNPs are promising non …