Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives

S Datta, D Aggarwal, N Sehrawat, M Yadav, V Sharma… - Phytomedicine, 2023 - Elsevier
Background: The liver is a well-known player in the metabolism and removal of drugs. Drug
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …

A clathrin-related protein FaRRP1/SCD2 integrates ABA trafficking and signaling to regulate strawberry fruit ripening

J Li, Y Shen - Journal of Biological Chemistry, 2023 - ASBMB
Abscisic acid (ABA) is a critical regulator for nonclimacteric fruit ripening such as in the
model plant of strawberry (Fragaria× ananassa). Although FaRRP1 is proposed to …

Identification of MDM2 as a prognostic and immunotherapeutic biomarker in a comprehensive pan-cancer analysis: A promising target for breast cancer, bladder …

J Zheng, F Miao, Z Wang, Y Ma, Z Lin, Y Chen, X Kong… - Life Sciences, 2023 - Elsevier
Background The murine double minute 2 (MDM2) gene is a crucial factor in the
development and progression of various cancer types. Multiple rigorous scientific studies …

Antibacterial activity and antibacterial mechanism of flavaspidic acid BB against Staphylococcus haemelyticus

J Liu, R Liu, R Deng, S Zheng, Z Shen - BMC microbiology, 2023 - Springer
Background Staphylococcus haemolyticus (S. haemolyticus) is the main etiological factor in
skin and soft tissue infections (SSTI). S. haemolyticus infections are an important concern …

[HTML][HTML] Phyllanthus emblica (Amla) methanolic extract regulates multiple checkpoints in 15-lipoxygenase mediated inflammopathies: Computational simulation and in …

MA Sharif, AM Khan, R Salekeen, MH Rahman… - Saudi Pharmaceutical …, 2023 - Elsevier
Amla (Phyllanthus emblica) has long been used in traditional folk medicine to prevent and
cure a variety of inflammatory diseases. In this study, the antioxidant activity (DPPH …

[HTML][HTML] Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and …

MNK Azam, P Biswas, MMI Tareq, MR Hossain… - Saudi Pharmaceutical …, 2024 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder arising from insulin deficiency and
defectiveness of the insulin receptor functioning on transcription factor where the body loses …

[PDF][PDF] Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements

CO Raharjo, CS Akbar, MQ Rahmalia - Journal of Pharmacy & …, 2024 - jppres.com
Abstract Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine
double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and …

Identification of Therapeutic Leads from Ficus hispida Fruit Phytochemicals against Prostate Cancer Using Pharmacoinformatic and Molecular Dynamics Simulation …

MDH Rahman, MA Rahman, MS Zahan, P Biswas… - bioRxiv, 2023 - biorxiv.org
Prostate cancer is one of the leading causes of death and the most common cancer type in
men. In this study, potential leads from the phytochemicals of Ficus hispida fruit were …

Evaluation of flavaspidic acid BB from Dryopteris fragrans (L.) Schott against resistant Staphylococcus haemelyticus in planktonic and biofilm forms

J Liu, R Liu, R Deng, S Zheng, Z Shen - 2023 - researchsquare.com
Background Staphylococcus haemolyticus (S. haemolyticus) is the main etiological factor in
skin and soft tissue infections (SSTI). S. haemolyticus infections are an important concern …

Computational Study of Phytopharmaceutical Antidiabetes Potential of Gorontalo Traditional Medicine Plants

A La Kilo, A Asisah, NI Ischak, M Paputungan… - Jurnal Kartika …, 2023 - jkk.unjani.ac.id
Diabetes Mellitus (DM) was a disease characterized by the occurrence of hyperglycemia.
This study aimed to analyze the activity of compounds in traditional medicinal plants as …