In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …

The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …

Conductance-based models of neural activity produce large amounts of data that can be
hard to visualize and interpret. We introduce visualization methods to display the dynamics …

Rationale: In cardiomyocytes, NaV1. 5 and Kir2. 1 channels interact dynamically as part of
membrane bound macromolecular complexes. Objective: The objective of this study was to …

We previously reported the feasibility and efficacy of a simulation-guided clinical catheter
ablation of atrial fibrillation (AF) in an in-silico AF model. We developed a highly efficient …

The mechanisms underlying atrial fibrillation (AF), the most common sustained cardiac
rhythm disturbance, remain elusive. Atrial fibrosis plays an important role in the development …

Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which
leads to impaired atrial function, adverse hemodynamic effects, and increased …

Although pulmonary vein isolation (PVI) gaps and extrapulmonary vein triggers contribute to
recurrence after atrial fibrillation (AF) ablation, their precise mechanisms remain unproven …

Gain-of-function mutations in KCNJ2-encoded Kir2. 1 channels underlie variant 3 (SQT3) of
the short QT syndrome, which is associated with atrial fibrillation (AF). Using biophysically …

Atrial fibrillation is the most common rhythm disturbance encountered in clinical practice.
Although often considered as solely arrhythmic in nature, current evidence has established …