Epigenetic modifications in stress response genes associated with childhood trauma
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …
Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances
M Karimi, P Sahandi Zangabad… - … applied materials & …, 2016 - ACS Publications
Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as
carriers that can be stimulated by changes in environmental parameters such as …
carriers that can be stimulated by changes in environmental parameters such as …
The many faces of estrogen signaling
P Vrtačnik, B Ostanek, S Mencej-Bedrač, J Marc - Biochemia medica, 2014 - hrcak.srce.hr
Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …
reproductive functions; however, our understanding of the role estrogens play in the human …
[HTML][HTML] Development and maintenance of regulatory T cells
N Ohkura, Y Kitagawa, S Sakaguchi - Immunity, 2013 - cell.com
Regulatory T (Treg) cells are a developmentally and functionally distinct T cell
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …
Modulating epigenetic modifications for cancer therapy
LJ Castro-Muñoz, E Vázquez Ulloa… - Oncology …, 2023 - spandidos-publications.com
Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …
earliest genomic aberrations occurring during cancer development and are closely related …
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
N Ohkura, M Hamaguchi, H Morikawa, K Sugimura… - Immunity, 2012 - cell.com
The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells,
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …
diseases. The epigenome differs between cell types and has until now only been …
HIF-1-independent mechanisms regulating metabolic adaptation in hypoxic cancer cells
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
L Luzhna, P Kathiria, O Kovalchuk - Frontiers in genetics, 2013 - frontiersin.org
Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …
and/or whole chromosomes that were not incorporated into the nucleus after cell division …
Pharmacophore-based virtual screening, 3D QSAR, Docking, ADMET, and MD simulation studies: An in silico perspective for the identification of new potential …
G Lanka, D Begum, S Banerjee, N Adhikari… - Computers in Biology …, 2023 - Elsevier
Abstract Histone deacetylase 3 (HDAC3) is an epigenetic regulator that involves gene
expression, apoptosis, and cell cycle progression, and the overexpression of HDAC3 is …
expression, apoptosis, and cell cycle progression, and the overexpression of HDAC3 is …