Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as
carriers that can be stimulated by changes in environmental parameters such as …

Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

Regulatory T (Treg) cells are a developmentally and functionally distinct T cell
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …

Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells,
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …

Abstract Histone deacetylase 3 (HDAC3) is an epigenetic regulator that involves gene
expression, apoptosis, and cell cycle progression, and the overexpression of HDAC3 is …