Allosteric regulation of G-protein-coupled receptors: from diversity of molecular mechanisms to multiple allosteric sites and their ligands
AO Shpakov - International Journal of Molecular Sciences, 2023 - mdpi.com
Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …
Nanobodies as Diagnostic and Therapeutic Tools for Cardiovascular Diseases (CVDs)
LA Bocancia-Mateescu, D Stan, AC Mirica, MG Ghita… - Pharmaceuticals, 2023 - mdpi.com
The aim of this review is to summarize some of the most recent work in the field of
cardiovascular disease (CVD) diagnosis and therapy, focusing mainly on the role of …
cardiovascular disease (CVD) diagnosis and therapy, focusing mainly on the role of …
Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State …
M Sencanski, S Glisic, V Kubale, M Cotman, J Mavri… - Biomolecules, 2024 - mdpi.com
This study assessed the suitability of the complementarity-determining region 2 (CDR2) of
the nanobody (Nb) as a template for the derivation of nanobody-derived peptides (NDPs) …
the nanobody (Nb) as a template for the derivation of nanobody-derived peptides (NDPs) …
Identification of a novel anti‐ROR1 nanobody through phage display and its biochemical characterization
L Kang, Y Dong, W Wang, Z Li, Y Wang… - Biotechnology and …, 2024 - Wiley Online Library
In this study, we aimed to develop nanobodies targeting receptor tyrosine kinase‐like
orphan receptor 1 (ROR1) for cancer diagnosis and therapy. We immunized alpacas with …
orphan receptor 1 (ROR1) for cancer diagnosis and therapy. We immunized alpacas with …
A Comprehensive Review on Therapeutic Potential of Nanobodies
Recently, nanobodies have taken center stage in research on drug discovery and
development. Several therapeutic possibilities using nanobodies are presently undergoing …
development. Several therapeutic possibilities using nanobodies are presently undergoing …
Splice Variants of G Protein-Coupled Receptors Expressed in Cancers: Effective Targeting with Monoclonal Antibodies and Antibody-Like Scaffolds As Ligands …
G protein-coupled receptors (GPCRs) form a superfamily of approximately 800–1000
receptors, including cell surface receptors that are internalized with activation and recycled …
receptors, including cell surface receptors that are internalized with activation and recycled …