According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and
aldehydic load is a hallmark of heart failure. Recently, different research groups have …

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization
concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart …

The ALDH2* 2 missense variant that commonly causes alcohol flushing reactions is the
single genetic polymorphism associated with the largest number of traits in humans. The …

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases
(mitochondriopathies) and many other infectious and non-infectious diseases including viral …

Aldehyde dehydrogenases (ALDHs) play an essential role in regulating malignant tumor
progression; however, their role in cholangiocarcinoma (CCA) has not been elucidated. We …

Accumulating evidence support the cardioprotective properties of the nuclear receptor
peroxisome proliferator activated receptor β/δ (PPARβ/δ); however, the underlying …

Alcoholism is accompanied with a high incidence of cardiac morbidity and mortality due to
the development of alcoholic cardiomyopathy, manifested as dilation of one or both …

Reduced bioavailability of the nitric oxide (NO) signaling molecule has been associated with
the onset of cardiovascular disease. One of the better-known and effective therapies for …

Ethanol can acutely and chronically alter cardiomyocyte and whole-organ function in the
heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic …