Chimeric antigen receptor (CAR) T cell therapy has shown impressive clinical efficacy in B
cell malignancies and multiple myeloma, leading to the approval of six CAR T cell products …

Chimeric antigen receptor (CAR) T cells are highly effective at targeting and eliminating cells
of the B cell lineage. CAR T cell therapy has become a standard-of-care treatment for …

Metastasis, the spread of cancer from a primary site to distant organs, is an important
challenge in oncology. This Review explores the complexities of immune escape …

T cells modified to express intelligently designed chimeric antigen receptors (CARs) are
exceptionally powerful therapeutic agents for relapsed and refractory blood cancers and …

Despite the use of 'high efficacy'disease‐modifying therapies, disease activity and clinical
progression of different immune‐mediated neurological diseases continue for some …

Background How distinct methods of host preconditioning impact the efficacy of adoptively
transferred antitumor T helper cells is unknown. Methods CD4+ T cells with a transgenic T …

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of
hematologic malignancies, offering remarkable remission rates in otherwise refractory …

Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in
achieving durable and potentially curative responses in patients with hematological …

ABSTRACT Introduction Systemic sclerosis (SSc) is the rheumatic disease with the highest
individual mortality rate with detrimental impact on quality of life. Cell-based therapies may …

Malignant tumors of the hematologic system have a high degree of malignancy and high
mortality rates. Chimeric antigen receptor T cell (CAR-T) therapy has become an important …