There is an epidemic of opioid use, abuse, and misuse in the United States, which results in
significant morbidity and mortality. It may be difficult to reduce perioperative opioid use given …

Opioid use has risen dramatically in the past three decades. In the USA, opioid overdose
has become a leading cause of unintentional death, surpassing motor vehicle accidents. A …

Abstract Editor's Perspective What We Already Know about This Topic The intraoperative
administration of methadone is effective in reducing postoperative pain Preventative …

Perioperative pain management is a unique challenge in patients undergoing spine surgery
due to the increased incidence of both pre-existing chronic pain conditions and chronic …

Serotonin-norepinephrine reuptake inhibitors (SNRIs) inhibit the presynaptic neuronal
uptake of serotonin and norepinephrine and prolong the effects of the monoamines in the …

Background We conducted a systematic review and meta-analysis to assess effects of
selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake …

Background Duloxetine is currently approved for chronic pain management; however,
despite some evidence, its utility in acute, postoperative pain remains unclear Aim of the …

Background Duloxetine administered during the acute perioperative period has been
associated with lesser postoperative pain and analgesic consumption. Study objectives The …

Objective Duloxetine has been recently used as a part of multimodal analgesia in
perioperative settings, yet the optimal dose of Duloxetine is not determined. Design A …

Background: Duloxetine hydrochloride (DUL) is an antidepressant included in the
pharmacological class of serotonin–norepinephrine reuptake inhibitors approved for the …