Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
P Redgrave, M Rodriguez, Y Smith… - Nature Reviews …, 2010 - nature.com
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a
fundamental pathological feature of Parkinson's disease. Studies in animals and humans …
fundamental pathological feature of Parkinson's disease. Studies in animals and humans …
The short-latency dopamine signal: a role in discovering novel actions?
P Redgrave, K Gurney - Nature reviews neuroscience, 2006 - nature.com
An influential concept in contemporary computational neuroscience is the reward prediction
error hypothesis of phasic dopaminergic function. It maintains that midbrain dopaminergic …
error hypothesis of phasic dopaminergic function. It maintains that midbrain dopaminergic …
Towards an executive without a homunculus: computational models of the prefrontal cortex/basal ganglia system
TE Hazy, MJ Frank, RC O'reilly - … Transactions of the …, 2007 - royalsocietypublishing.org
The prefrontal cortex (PFC) has long been thought to serve as an 'executive'that controls the
selection of actions and cognitive functions more generally. However, the mechanistic basis …
selection of actions and cognitive functions more generally. However, the mechanistic basis …
[PDF][PDF] Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection
M Stephenson-Jones, E Samuelsson, J Ericsson… - Current biology, 2011 - cell.com
Background Although the basal ganglia are thought to play a key role in action selection in
mammals, it is unknown whether this mammalian circuitry is present in lower vertebrates as …
mammals, it is unknown whether this mammalian circuitry is present in lower vertebrates as …
The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.
MD Humphries, TJ Prescott - Progress in neurobiology, 2010 - Elsevier
The basal ganglia are often conceptualised as three parallel domains that include all the
constituent nuclei. The 'ventral domain'appears to be critical for learning flexible behaviours …
constituent nuclei. The 'ventral domain'appears to be critical for learning flexible behaviours …
Understanding brain functional architecture through robotics
TJ Prescott, SP Wilson - Science Robotics, 2023 - science.org
Robotics is increasingly seen as a useful test bed for computational models of the brain
functional architecture underlying animal behavior. We provide an overview of past and …
functional architecture underlying animal behavior. We provide an overview of past and …
The basal ganglia and cortex implement optimal decision making between alternative actions
Neurophysiological studies have identified a number of brain regions critically involved in
solving the problem of action selection or decision making. In the case of highly practiced …
solving the problem of action selection or decision making. In the case of highly practiced …
A physiologically plausible model of action selection and oscillatory activity in the basal ganglia
MD Humphries, RD Stewart… - Journal of Neuroscience, 2006 - Soc Neuroscience
The basal ganglia (BG) have long been implicated in both motor function and dysfunction. It
has been proposed that the BG form a centralized action selection circuit, resolving conflict …
has been proposed that the BG form a centralized action selection circuit, resolving conflict …
The hidden sister of motor fluctuations in Parkinson's disease: A review on nonmotor fluctuations
R Martínez‐Fernández, E Schmitt… - Movement …, 2016 - Wiley Online Library
Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …
Action suppression reveals opponent parallel control via striatal circuits
The direct and indirect pathways of the basal ganglia are classically thought to promote and
suppress action, respectively. However, the observed co-activation of striatal direct and …
suppress action, respectively. However, the observed co-activation of striatal direct and …