Using machine learning approaches for multi-omics data analysis: A review
With the development of modern high-throughput omic measurement platforms, it has
become essential for biomedical studies to undertake an integrative (combined) approach to …
become essential for biomedical studies to undertake an integrative (combined) approach to …
Gut microbial metabolites as multi-kingdom intermediates
KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …
metabolites. These metabolites exert their effects within the host as signalling molecules and …
Human metabolome variation along the upper intestinal tract
Most processing of the human diet occurs in the small intestine. Metabolites in the small
intestine originate from host secretions, plus the ingested exposome and microbial …
intestine originate from host secretions, plus the ingested exposome and microbial …
Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
Organoids have extensive therapeutic potential and are increasingly opening up new
avenues within regenerative medicine. However, their clinical application is greatly limited …
avenues within regenerative medicine. However, their clinical application is greatly limited …
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
High-grade serous carcinoma has a poor prognosis, owing primarily to its early
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics
Novel metabolites distinct from canonical pathways can be identified through the integration
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …
Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
We identified the main changes in serum metabolites associated with severe (n= 46) and
mild (n= 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …
mild (n= 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …
Metabolomics enables precision medicine:“a white paper, community perspective”
Abstract Introduction: Background to metabolomics Metabolomics is the comprehensive
study of the metabolome, the repertoire of biochemicals (or small molecules) present in …
study of the metabolome, the repertoire of biochemicals (or small molecules) present in …
One step forward for reducing false positive and false negative compound identifications from mass spectrometry metabolomics data: new algorithms for constructing …
False positive and false negative peaks detected from extracted ion chromatograms (EIC)
are an urgent problem with existing software packages that preprocess untargeted liquid or …
are an urgent problem with existing software packages that preprocess untargeted liquid or …
Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics
G Paglia, AJ Smith, G Astarita - Mass spectrometry reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …