Heterogeneity of thyroid cancer

E Chmielik, D Rusinek, M Oczko-Wojciechowska… - Pathobiology, 2018 - karger.com
There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …

[HTML][HTML] A narrative review of genetic alterations in primary thyroid epithelial cancer

C Romei, R Elisei - International journal of molecular sciences, 2021 - mdpi.com
Thyroid carcinoma is the most frequent endocrine neoplasia. Different types of thyroid
carcinoma are described: well-differentiated papillary thyroid carcinoma (PTC), poorly …

[HTML][HTML] Genetic landscape of somatic mutations in a large cohort of sporadic medullary thyroid carcinomas studied by next-generation targeted sequencing

R Ciampi, C Romei, T Ramone, A Prete, A Tacito… - IScience, 2019 - cell.com
Summary Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid
tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the …

[HTML][HTML] Lenvatinib: Role in thyroid cancer and other solid tumors

ME Cabanillas, MA Habra - Cancer treatment reviews, 2016 - Elsevier
Despite recent breakthroughs in treatment of advanced thyroid cancers, prognoses remain
poor. Treatment of advanced, progressive disease remains challenging, with limited …

[HTML][HTML] Associations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis

C Liu, T Chen, Z Liu - World journal of surgical oncology, 2016 - Springer
Background The objective of this study is to perform a meta-analysis to evaluate the
associations between the BRAF V600E mutation status and aggressive clinicopathological …

[HTML][HTML] BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis

F Li, G Chen, C Sheng, AM Gusdon… - Endocrine-related …, 2015 - ncbi.nlm.nih.gov
The prognostic value of the BRAFV600E mutation, resulting in poor clinical outcomes of
papillary thyroid carcinoma, has been generally confirmed. However, the association of …

[HTML][HTML] Do histological, immunohistochemical, and metabolic (radioiodine and fluorodeoxyglucose uptakes) patterns of metastatic thyroid cancer correlate with …

D Deandreis, A Al Ghuzlan… - Endocrine-related …, 2011 - erc.bioscientifica.com
The aim of this study is to search for relationships between histology, radioiodine (131 I)
uptake, fluorodeoxyglucose (FDG) uptake, and disease outcome in patients with metastatic …

[HTML][HTML] BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications

E Oikonomou, E Koustas, M Goulielmaki, A Pintzas - Oncotarget, 2014 - ncbi.nlm.nih.gov
As the increased knowledge of tumour heterogeneity and genetic alterations progresses, it
exemplifies the need for further personalized medicine in modern cancer management …

Clinicopathologic Implications of the BRAFV600E Mutation in Papillary Thyroid Cancer: A Subgroup Analysis of 3130 Cases in a Single Center

JY Lim, SW Hong, YS Lee, BW Kim, CS Park… - Thyroid, 2013 - liebertpub.com
Background: The BRAF mutation has been shown to be associated with aggressive
clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies …

TERT mRNA Expression as a Novel Prognostic Marker in Papillary Thyroid Carcinomas

A Tanaka, M Matsuse, V Saenko, T Nakao… - Thyroid, 2019 - liebertpub.com
Background: Telomerase reverse transcriptase (TERT) promoter mutations have been found
in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor …