Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors

TM Kono, EK Sims, DR Moss, W Yamamoto, G Ahn… - Stem …, 2014 - academic.oup.com
Adipose-derived stromal/stem cells (ASCs) ameliorate hyperglycemia in rodent models of
islet transplantation and autoimmune diabetes, yet the precise human ASC (hASC)-derived …

Pancreatic duct cells as a source of VEGF in mice

X Xiao, K Prasadan, P Guo, Y El-Gohary, S Fischbach… - Diabetologia, 2014 - Springer
Aims/hypothesis Vascular endothelial growth factor (VEGF) is essential for proper pancreatic
development, islet vascularisation and insulin secretion. In the adult pancreas, VEGF is …

Generation of insulin‐producing cells from human‐induced pluripotent stem cells using a stepwise differentiation protocol optimized with platelet‐rich plasma

SE Enderami, Y Mortazavi, M Soleimani… - Journal of cellular …, 2017 - Wiley Online Library
Studies on patient‐specific human‐induced pluripotent stem cells (hiPSCs) as well as a
series of autologous growth factors presumably will reveal their many benefits for cell base …

VEGF-conjugated alginate hydrogel prompt angiogenesis and improve pancreatic islet engraftment and function in type 1 diabetes

N Yin, Y Han, H Xu, Y Gao, T Yi, J Yao, L Dong… - Materials Science and …, 2016 - Elsevier
Type 1 diabetes was a life-long disease that affected numerous people around the world.
Insulin therapy has its limitations that may involve hyperglycemia and heavy burden of …

Systems biology approach reveals genome to phenome correlation in type 2 diabetes

P Jain, S Vig, M Datta, D Jindel, AK Mathur, SK Mathur… - PloS one, 2013 - journals.plos.org
Genome-wide association studies (GWASs) have discovered association of several loci with
Type 2 diabetes (T2D), a common complex disease characterized by impaired insulin …

Islet macrophages are associated with islet vascular remodeling and compensatory hyperinsulinemia during diabetes

M Chittezhath, D Gunaseelan… - American Journal …, 2019 - journals.physiology.org
β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

[HTML][HTML] Plasma-derived exosomal miRNAs as potentially novel biomarkers for latent autoimmune diabetes in adults

W Fan, H Pang, X Li, Z Xie, G Huang, Z Zhou - Diabetes Research and …, 2023 - Elsevier
Aim To characterize the exosomal miRNA profiles of latent autoimmune diabetes in adults
(LADA) and evaluate the biomarker potential of selected miRNAs to distinguish LADA from …

Long-term survival and glycemic control with toceranib phosphate and prednisone for a metastatic canine insulinoma

BK Flesner, JM Fletcher, T Smithee… - Journal of the …, 2019 - meridian.allenpress.com
Canine insulinoma is a highly metastatic neoplasm that is associated with a guarded to poor
prognosis in dogs with distant metastases. A median survival of 6 mo has been reported for …

The association of serum vascular endothelial growth factor and ferritin in diabetic microvascular disease

L Guo, F Jiang, YT Tang, MY Si… - Diabetes Technology & …, 2014 - liebertpub.com
Background: Vascular endothelial growth factor (VEGF) is involved in the pathogenesis of
diabetic microvascular disease. Most diabetes patients have higher serum levels of ferritin …

Synergy of bone marrow transplantation and curcumin ensue protective effects at early onset of diabetes in mice 在早期发病的糖尿病小鼠中使用骨髓移植和姜黄素联合 …

A Arivazhagan, S Krishna, S Yadav… - Journal of …, 2015 - Wiley Online Library
摘要背景: 本研究的目的是调查链脲霉素(STZ) 诱导的糖尿病小鼠糖尿病早期发病对促血管生成
信号通路, 骨髓细胞总数, 器官(胰腺与肾脏) 损害的影响以及使用姜黄素与骨髓移植联合治疗后 …