T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

Checkpoint immunotherapy holds great potential to treat malignancies via blocking the
immunosuppressive signaling pathways, which however suffers from inefficiency and off …

As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …

Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple
tumours. However, only a few patients respond to ICIs, which has generated considerable …

Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies,
overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin …

Gut microbiome has been increasingly recognized for its influence on a diverse array of
human diseases including cancer, and may also influence the outcome of cancer therapies …

The effect of gut bacteria on the response to immune checkpoint inhibitors (ICIs) has been
studied, but the relationship between fungi and ICI responses is not fully understood. Herein …