Theranostic fluorescent probes
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …
Peptide‐Appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic–Immunometabolic Therapy of Spinal‐Metastasized Tumors
Despite recent advancements in cancer immunotherapy, challenges have yet to be
surmounted to achieve two major goals of magnifying antitumor immunity and remodeling …
surmounted to achieve two major goals of magnifying antitumor immunity and remodeling …
Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint
NK Verma, BHS Wong, ZS Poh, A Udayakumar… - …, 2022 - thelancet.com
The tumour microenvironment (TME) imposes a major obstacle to infiltrating T-lymphocytes
and suppresses their function. Several immune checkpoint proteins that interfere with …
and suppresses their function. Several immune checkpoint proteins that interfere with …
Identification and validation of an anoikis-associated gene signature to predict clinical character, stemness, IDH mutation, and immune filtration in glioblastoma
Z Sun, Y Zhao, Y Wei, X Ding, C Tan… - Frontiers in …, 2022 - frontiersin.org
Background Glioblastoma (GBM) is the most prominent and aggressive primary brain tumor
in adults. Anoikis is a specific form of programmed cell death that plays a key role in tumor …
in adults. Anoikis is a specific form of programmed cell death that plays a key role in tumor …
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer
JJ Li, JH Wang, T Tian, J Liu, YQ Zheng, HY Mo… - Nature …, 2023 - nature.com
Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell
X Zhu, K Li, G Liu, R Wu, Y Zhang, S Wang, M Xu… - Gut …, 2023 - Taylor & Francis
Recent studies have demonstrated that the antitumor immunity of immune cells can be
modulated by gut microbiota and their metabolites. However, the underlying mechanisms …
modulated by gut microbiota and their metabolites. However, the underlying mechanisms …
Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms
B Wang, Y Han, Y Zhang, Q Zhao, H Wang, J Wei… - Cell & Bioscience, 2023 - Springer
Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-
specific T lymphocyte immunity have opened up new avenues for the treatment of various …
specific T lymphocyte immunity have opened up new avenues for the treatment of various …
Combined angiogenesis and PD-1 inhibition for immunomodulatory TNBC: concept exploration and biomarker analysis in the FUTURE-C-Plus trial
SY Wu, Y Xu, L Chen, L Fan, XY Ma, S Zhao, XQ Song… - Molecular cancer, 2022 - Springer
Background Immune checkpoint inhibitors had a great effect in triple-negative breast cancer
(TNBC); however, they benefited only a subset of patients, underscoring the need to co …
(TNBC); however, they benefited only a subset of patients, underscoring the need to co …
The DNA damage response and inflammation in cancer
Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Solid tumours display a limited response to immunotherapies. By contrast, haematological
malignancies exhibit significantly higher response rates to immunotherapies as compared …
malignancies exhibit significantly higher response rates to immunotherapies as compared …