Despite the ups and downs in the field over three decades, the science of gene therapy has
continued to advance and provide enduring treatments for increasing number of diseases …

Despite advances in cancer treatment, immune checkpoint blockade (ICB) only achieves
complete response in some patients, illustrating the need to identify resistance mechanisms …

Chemo‐immunotherapy has shown great success in boosting systemic anti‐tumor effects in
the clinic. However, cancer cells can escape the maximum impact of chemotherapy through …

Importance The development of oncology drugs is expensive and beset by a high attrition
rate. Analysis of the costs and causes of translational failure may help to reduce attrition and …

Cuproptosis, a new type of programmed cell death, is involved in the development and
progression of malignancies. The study of cuproptosis‐associated long non‐coding RNAs …

Immune checkpoint blockade (ICB) has rapidly transformed the treatment paradigm for
various cancer types. Multiple single or combinations of ICB treatments have been approved …

Metal–organic frameworks (MOFs) take on highly ordered self-assembled structures and
have gained much attention due to their intriguing structural features and enormous …

Simple Summary Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment
of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients …

Abstract G-quadruplex (G4) binders have been investigated to discover new anticancer
drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the …

Immunotherapy has greatly improved cancer outcomes, yet variability in response and off-
target tissue damage can occur with these treatments, including immune checkpoint …