Targeting intratumoral hypoxia to enhance anti-tumor immunity
GL Semenza - Seminars in Cancer Biology, 2023 - Elsevier
Cancers express a large battery of genes by which they establish an immunosuppressive
tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through …
tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through …
[HTML][HTML] Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint …
Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in
cancer treatment, but responses are limited to a fraction of patients. Therefore, sustained …
cancer treatment, but responses are limited to a fraction of patients. Therefore, sustained …
An In Vivo Self‐Assembled Bispecific Nanoblocker for Enhancing Tumor Immunotherapy
XJ Hu, NY Zhang, DY Hou, ZJ Wang… - Advanced …, 2023 - Wiley Online Library
Anti‐PD‐L1 monoclonal antibody has achieved substantial success in tumor
immunotherapy by T‐cells activation. However, the excessive accumulation of extracellular …
immunotherapy by T‐cells activation. However, the excessive accumulation of extracellular …
[HTML][HTML] In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity
Z Lin, F Meng, Y Ma, C Zhang, Z Zhang, Z Yang, Y Li… - Bioactive Materials, 2024 - Elsevier
Immune checkpoint blockade (ICB) therapy potently revives T cell's response to cancer.
However, patients suffered with tumors that had inadequate infiltrated immune cells only …
However, patients suffered with tumors that had inadequate infiltrated immune cells only …
Aggregation‐induced‐emission photosensitizer‐loaded nano‐superartificial dendritic cells with directly presenting tumor antigens and reversed immunosuppression …
Z Sun, J Liu, Y Li, X Lin, Y Chu, W Wang… - Advanced …, 2023 - Wiley Online Library
The success of tumor immunotherapy highlights the potential of harnessing immune system
to fight cancer. Activating both native T cells and exhausted T cells is a critical step for …
to fight cancer. Activating both native T cells and exhausted T cells is a critical step for …
Ultradeep photothermal therapy strategies
Y Chu, XQ Xu, Y Wang - The Journal of Physical Chemistry Letters, 2022 - ACS Publications
Photothermal therapy (PTT) mediated by the second near-infrared light (NIR-II) is
considered as the most promising PTT in deep tissues due to the superior penetrability of …
considered as the most promising PTT in deep tissues due to the superior penetrability of …
M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance
N Zheng, T Wang, Q Luo, Y Liu, J Yang, Y Zhou… - …, 2023 - Taylor & Francis
ABSTRACT T-cell-based immune checkpoint blockade therapy (ICB) can be undermined by
local immunosuppressive M2-like tumor-associated macrophages (TAMs). However …
local immunosuppressive M2-like tumor-associated macrophages (TAMs). However …
Systematic pan-cancer analysis identifies APOC1 as an immunological biomarker which regulates macrophage polarization and promotes tumor metastasis
L Ren, J Yi, Y Yang, W Li, X Zheng, J Liu, S Li… - Pharmacological …, 2022 - Elsevier
Abstract Apolipoprotein C1 (APOC1) has been found to play an essential part in proliferation
and metastasis of numerous cancers, but related mechanism has not been elucidated …
and metastasis of numerous cancers, but related mechanism has not been elucidated …
[HTML][HTML] Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells
Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved
outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials. gov: NCT03563716) when …
outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials. gov: NCT03563716) when …
[HTML][HTML] Immunotherapy in breast cancer: an overview of current strategies and perspectives
V Debien, A De Caluwé, X Wang… - NPJ Breast …, 2023 - nature.com
Recent progress in immunobiology has led the way to successful host immunity
enhancement against breast cancer. In triple-negative breast cancer, the combination of …
enhancement against breast cancer. In triple-negative breast cancer, the combination of …