Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention

MF McCarty - Medical hypotheses, 2012 - Elsevier
A recent meta-analysis examining long-term mortality in subjects who participated in
controlled studies evaluating the impact of daily aspirin on vascular risk, has concluded that …

Changes of immunocytic phenotypes and functions from human colorectal adenomatous stage to cancerous stage: Update

Y Shi, Z Li, W Zheng, X Liu, C Sun, JB Laugsand, Z Liu… - Immunobiology, 2015 - Elsevier
It is believed that chronic inflammation as seen in patients with ulcerative colitis significantly
increases the colorectal cancer (CRC) risk and functions as the main driving force for the …

Cox-2 gene variants in migraine

S Dasdemir, Y Cetinkaya, M Gencer, E Ozkok, M Aydin… - Gene, 2013 - Elsevier
PURPOSE: Migraine is a multifactorial and complex disorder, and any clear diagnostic
marker to assess the status of the migraineurs has not been established, yet. Nonsteroidal …

Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers

T Ohta, M Takahashi, A Ochiai - Cancer Letters, 2006 - Elsevier
The present study was conducted to investigate protein levels of inducible NO synthase
(iNOS) and cayclooxygenase-2 (COX-2) in human colon cancer tissues. Significant increase …

Progressive cellular response in the lamina propria of the colorectal adenoma–carcinoma sequence

G Cui, A Yuan, B Vonen, J Florholmen - Histopathology, 2009 - Wiley Online Library
Aims: The lamina propria is inevitably involved in epithelial transformation. The aim was to
evaluate the dynamic cellular changes in the tumour lamina propria throughout the …

α2β1 integrin signalling enhances cyclooxygenase‐2 expression in intestinal epithelial cells

OJ Broom, R Massoumi… - Journal of cellular …, 2006 - Wiley Online Library
Inflammatory bowel diseases (IBD) are linked to an increased risk of developing colon
cancer, by inflammatory mediators and alterations to the extracellular matrix (ECM). The …

Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma

Y Kato, H Nishihara, H Mohri, H Kanno… - Brain tumor …, 2014 - Springer
Tumorigenic activity of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the production
of prostaglandins (PGs), has been proved for some types of cancer, including brain tumors …

Prostanoid EP1 receptor as the target of (−)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro

J Jin, Y Chang, W Wei, Y He, S Hu, D Wang… - Acta Pharmacologica …, 2012 - nature.com
Aim: To investigate the effects of (−)-epigallocatechin-3-gallate (EGCG), an active compound
in green tea, on prostaglandin E 2 (PGE 2)-induced proliferation and migration, and the …

[HTML][HTML] Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication

SH Park, N Kangwan, JM Park, EH Kim… - World Journal of …, 2013 - ncbi.nlm.nih.gov
Abstract Although the International Agency for Research on Cancer declared Helicobacter
pylori (H. pylori) as a definite human carcinogen in 1994, the Japanese Society for …

Catalpa seed oil rich in 9t, 11t, 13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats

R Suzuki, Y Yasui, H Kohno… - Oncology …, 2006 - spandidos-publications.com
Catalpa (Catalpa ovata) seed oil (CPO) is a unique oil that contains a high amount of 9trans,
11trans, 13cis-conjugated linolenic acid. In the present study, we investigated whether …