Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
[HTML][HTML] Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia
B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
[HTML][HTML] Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …
the aging world population. Advances in neurovascular biology have revealed an intricate …
[HTML][HTML] A systematic review of glucose transport alterations in Alzheimer's disease
N Kyrtata, HCA Emsley, O Sparasci… - Frontiers in …, 2021 - frontiersin.org
Introduction: Alzheimer's disease (AD) is characterized by cerebral glucose
hypometabolism. Hypometabolism may be partly due to reduced glucose transport at the …
hypometabolism. Hypometabolism may be partly due to reduced glucose transport at the …
The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging
The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …
Alzheimer's disease and other neurodegenerative dementias in comorbidity: a clinical and neuropathological overview
R Matej, A Tesar, R Rusina - Clinical biochemistry, 2019 - Elsevier
Neuropathological diagnostic criteria of neurodegenerative disorders are based on the
presence of specific inclusions in a specific area of brain tissue that correlate with clinical …
presence of specific inclusions in a specific area of brain tissue that correlate with clinical …
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer's disease
Reductions of baseline cerebral blood flow (CBF) of∼ 10–20% are a common symptom of
Alzheimer's disease (AD) that appear early in disease progression and correlate with the …
Alzheimer's disease (AD) that appear early in disease progression and correlate with the …
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
E Nutma, JA Stephenson, RP Gorter, J de Bruin… - Brain, 2019 - academic.oup.com
The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
Loss of capillary pericytes and the blood–brain barrier in white matter in poststroke and vascular dementias and Alzheimer's disease
R Ding, Y Hase, KE Ameen‐Ali, M Ndung'u… - Brain …, 2020 - Wiley Online Library
White matter (WM) disease is associated with disruption of the gliovascular unit, which
involves breach of the blood–brain barrier (BBB). We quantified pericytes as components of …
involves breach of the blood–brain barrier (BBB). We quantified pericytes as components of …