Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …

Gram‐negative resistance has reached a crucial point, with emergence of pathogens
resistant to most or all available antibiotics. Ceftazidime‐avibactam is a newly approved …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

In recent years there have been tremendous strides in understanding the relationship
between the pharmacodynamics of β‐lactams and microbiologic response. For β‐lactams, in …

Ceftolozane is a new cephalosporin with potent activity against Pseudomonas aeruginosa
and Enterobacteriaceae. A neutropenic murine thigh infection model was used to determine …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

There are some 43 small molecules in the antibiotic development pipeline from late
preclinical stage (7 compounds) through Phase 1 (11 molecules), Phase 2 (13 molecules) to …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

Objectives The combination of aztreonam/avibactam has promising activity against MDR
Gram-negative pathogens producing metallo-β-lactamases (MBLs), such as New Delhi MBL …

Introduction: Identifying the optimized dosing regimen and algorithm is critical in the
development of antibiotics. Suboptimal regimens and inappropriate choice of drug give rise …